Our seminar series is free and available for anyone to attend. Unless otherwise stated, seminars take place on Wednesday afternoons at 2pm in the Kilburn Building during teaching season.

If you wish to propose a seminar speaker please contact Antoniu Pop.


The MURDOCK Study: Building a Community-based Registry & Biorepository for Disease Reclassification

  • Speaker:   Dr.  Jessica Tenenbaum  (Duke Translational Medicine Institute)
  • Host:   Carole Goble
  • 19th September 2014 at 14:00 in Kilburn Building. Atlas Suite
In this talk, I will describe the MURDOCK Study (Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis), a multi-tiered, longitudinal study designed to enable classification of diseases using clinically annotated biospecimen collections, -omic technologies, and electronic health records. Enrollment for the study in Cabarrus County, North Carolina and adjacent zip codes began in 2009, and ~10,700 of the anticipated 50,000 participants have enrolled to date. Participants in the MURDOCK Study consent to provide both information and biospecimens, annual follow-up and re-contact for future studies, and access to electronic health records. The MURDOCK Integrated Data Repository (MIDR) is the informatics keystone of the project, pulling together participant reported (complete) and electronic health record data (in progress), as well as biospecimen and consent data and omics metadata using the i2b2 platform. I will describe the current state of the project, as well as challenges and best practices identified along the way.


Dr. Tenenbaum is Associate Director for Bioinformatics for the Duke Translational Medicine Institute (DTMI). Her primary areas of research are 1. Infrastructure and standards to enable research collaboration and integrative data analysis, and 2. Informatics to enable precision medicine. At Duke, Dr. Tenenbaum oversees development of the MURDOCK Integrated Data Repository (MIDR) for the management of clinical, omic, biobanking, and consent data as well as experimental and protocol metadata in the context of the MURDOCK Study. Nationally, Dr. Tenenbaum chaired the Scientific Program Committee for the American Medical Informatics Association's (AMIA) 2013 Summit on Translational Bioinformatics, is Chair Elect for the American Medical Informatics Association's Genomics Working Group, and is an Associate Editor for the Journal of Biomedical Informatics. After earning her bachelor's degree in biology from Harvard, Dr. Tenenbaum worked as a program manager at Microsoft Corporation in Redmond, WA for six years before pursuing a PhD in biomedical informatics at Stanford University. Her doctoral research focused on integration and analysis of disparate "-omic" scale datasets, and mining publicly available data for insights into human disease.
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